Project: iedb_v5
Class EPITOPE

Concrete Class Extends 
        :THING
 
Direct Instances:
None
 
Direct Subclasses:
None
 
Class Documentation:
An epitope is defined as the chemical structure recognized by antigen specific receptors of the immune system (antibodies and/or T cell receptors). In the case of most T cell epitopes, the epitope is defined as the structure that is presented in association with specific MHC molecules, and is bound by the variable regions of specific TCRs. Likewise, a B cell epitope is any structure bound by antibodies (monoclonal or polyclonal) through their variable regions. Both linear and conformational epitopes are considered within the scope of our project. For IEDB, even if no TCR is known to bind the MHC bound peptide it will be included in the database.


Template Slots
Slot name Documentation Type Allowed Values/Classes Cardinality Default
has Epitope Structure Inherits all the slots of Epitope Structure Class

Epitope structure captures the physical and chemical features of an epitope.

Class  Epitope Structure  1:1   
has Epitope Source Inherits all the slots of Epitope Source class

Class  Epitope Source  1:1   
has Reference Captures the Reference information from where the Epitope and its related were obtained.

Class  REFERENCE  1:1   
has MHC Binding Captures the details of MHC molecules and epitope-MHC binding information.

Class  MHC BINDING  0:*   
has Naturally Processed Ligands Captures the information about T Cell responsed that are arise from Natural processing of peptides by Antigen Presenting Cells (APC).

Class  NATURALLY PROCESSED LIGAND  0:*   
has T Cell Response Captures the information about T Cell responses.

Class  T CELL RESPONSE  0:*   
has B Cell Response Captures information about B Cell responses.

Class  B CELL RESPONSE  0:*   

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Generated on Thu Jun 02 12:31:05 PDT 2005